FDA Approves New Treatment for Rare Metabolic Disorder: A Breakthrough for PKU Patients
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Vitamins
Micro and Macronutrients Micronutrients are substances required in very small amounts (mg or μg) and that mainly function as co-factors of enzymes (< 0.005% body weight). Examples include: Vitamins Trace minerals (Fe, Cu, F, Zn, I, Se, Mn, Mo, Cr, Read More …
Integration and Starvation
Integration and Starvation Fig: Metabolic interrelationship of major pathways of energy metabolism Metabolic integration Phases of catabolism [All the major biomolecules – carbohydrates, lipids and proteins undergo catabolism to finally yield acetyl CoA which is further oxidised in the citric Read More …
Mnemonics
Cell membrane and Transport 1. Components of Cell Membrane (Fluid Mosaic Model) Mnemonic: “Phat People Can Make Fun Friends” P – PhospholipidsP – Proteins (Integral & Peripheral)C – CholesterolM – Membrane carbohydrates (Glycolipids, Glycoproteins)F – Fluid mosaicF – Flexibility 2. Read More …
Clinical Cases of Immunology
Subsection: Immunology Case Scenario 1: Question: A 25-year-old man presents to the clinic with complaints of high-grade fever, malaise, and sore throat for the past 3 days. On examination, he has enlarged cervical lymph nodes and a positive rapid antigen Read More …
Clinical Cases of Hemoglobin Metabolism
Subsection: Heme synthesis Case Scenario 1: A 4-year-old boy is brought to the pediatric clinic with complaints of abdominal pain, dark-colored urine, and photosensitivity. His mother also reports behavioral changes such as irritability and episodes of confusion. Urine examination reveals Read More …
Chemistry and Metabolism of Hemoglobin
Hemoproteins Heme as prosthetic group The heme group serves to reversibly bind oxygen Haemoglobin – RBCs Myoglobin – Muscles Cytochromes – heme group serves as e– carrier Catalase – it catalyses H2O2 Hemoglobin Conjugated protein Red blood pigment found in Read More …
Clinical Cases of Immunity
Subsection: Immunology Case Scenario 1: A 25-year-old man presents to the clinic with complaints of high-grade fever, malaise, and sore throat for the past 3 days. On examination, he has enlarged cervical lymph nodes and a positive rapid antigen test Read More …
Clinical Cases of Extracellular Matrix
Case Scenario 1: A 2-year-old child is brought to the pediatrician due to suspected child abuse. On examination, the child has blue sclerae, hearing loss in both ears, and multiple long bone fractures (both recent and healing). What is the Read More …
Chemistry and metabolism of Nucleotides & Nucleic acids
Chemistry of Nucleotides & Nucleic Acids There are two types of nucleic acids: deoxyribonucleic acids (DNA) and ribonucleic acids (RNA). Primarily, nucleic acids serve as repositories and transmitters of genetic information. DNA was discovered in 1869 by Johann Friedrich Miescher, Read More …