Nobel Prize 2025: Medicine award to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi
Their pioneering work on peripheral immune tolerance revealed how a special class of immune cells, known as regulatory T cells, act as guardians against autoimmune disease.
The Nobel Prize in Physiology or Medicine 2025 has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for groundbreaking discoveries that explain how the body’s immune system is kept in check to prevent it from attacking its own organs.
Mary E. Brunkow (born 1961) earned her Ph.D. from Princeton University, USA, and currently serves as Senior Program Manager at the Institute for Systems Biology in Seattle. Fred Ramsdell (born 1960) received his Ph.D. in 1987 from the University of California, Los Angeles, and is now Scientific Advisor at Sonoma Biotherapeutics, San Francisco.
Their pioneering work on peripheral immune tolerance revealed how a special class of immune cells, known as regulatory T cells, act as guardians against autoimmune disease.
Every day, the immune system defends us from thousands of invading microbes. But many pathogens mimic human cells to evade detection, making it vital for the immune system to distinguish between foreign threats and the body’s own tissues.
The laureates’ work answered this long-standing question by uncovering the mechanisms behind peripheral tolerance, the immune system’s ability to avoid self-harm.
https://www.indiatoday.in/science/story/nobel-prize-2025-medicine-award-winners-2798537-2025-10-06